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Real members of MyEpilepsyTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyEpilepsyTeam Member asked a question 💭
Bulawayo, Zimbabwe
October 26, 2025
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A MyEpilepsyTeam Member

Wow. Quality of medical care in your country is amazing. Plus you have neurologists who do follow ups, here in Zimbabwe they are very scarce. Plus follow ups on how the meds are affecting you and recommending supplements is only possible if you have enough money for a private hospital.

November 1, 2025
A MyEpilepsyTeam Member

I have not had any pain in my bones, but I have also learned that we all may react differently.

October 30, 2025
A MyEpilepsyTeam Member

@A MyEpilepsyTeam Member , Apparently long term use of some Epilepsy medications can possibly cause Osteoporosis. I’m 47 & have been on Depakote since my mid teens or early 20’s & when I started seeing an adult Neurologist in 2015 or so, he asked if I was aware that long term use of Depakote could possibly cause Osteoporosis & I said no & so he did a bone density test & that showed that I have Osteopenia in my left hip & so he recommended I take Vitamin D & he continued me on my Depakote. My current Neurologist still has me on Depakote but also has me taking Vitamin D but keeps a watch on my bloodwork & last time or so noticed that my Vitamin D was a little high & recommended not taking as much, because I take a Multivitamin & was also taking the Vitamin D every night & so taking both every day is likely why my Vitamin D was high & so now I take the Vitamin D every other night or so. Sometimes a person might shake a little due to their medications & you want to keep a watch on that because your medication might need to be adjusted. Take care. Your friend in Texas, Becky

October 26, 2025
MyEpilepsyTeam

Can antiseizure medications cause painful bones?

Antiseizure medications don't typically cause bone pain directly, but some can lead to bone loss and weakened bones over time, which may increase your risk of fractures and related discomfort.

Certain antiepileptic drugs (AEDs) have been linked to lower bone mineral density and Show Full Answer

Can antiseizure medications cause painful bones?

Antiseizure medications don't typically cause bone pain directly, but some can lead to bone loss and weakened bones over time, which may increase your risk of fractures and related discomfort.

Certain antiepileptic drugs (AEDs) have been linked to lower bone mineral density and a higher risk of osteoporosis. Long-term use of some AEDs can raise fracture risk by as much as 79 percent, and people with epilepsy are already two to six times more likely to experience bone fractures compared to the general population.

Medications most associated with bone loss include:
* Phenytoin (Dilantin)
* Divalproex sodium (Depakote)
* Primidone
* Carbamazepine (Tegretol, Carbatrol)

These medications may affect bone health by interfering with vitamin D levels, encouraging bone turnover, or blocking the formation of new bone tissue.

If you're experiencing bone pain or concerned about bone health, talk with your neurology team. They can monitor for side effects, recommend vitamin D supplements, adjust your dosage, or consider switching to another medication.

Newer AEDs like levetiracetam (Keppra), zonisamide, and topiramate may carry lower long-term bone health risks compared to older treatments.

October 26, 2025

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