When medications aren't effectively controlling seizures in Lennox-Gastaut Syndrome (LGS), several alternative treatment options are available. Vagus Nerve Stimulation (VNS) therapy uses a device implanted in the chest that sends mild electrical signals to the brain through the vagus nerve. Studies show that over half of Show Full Answer
When medications aren't effectively controlling seizures in Lennox-Gastaut Syndrome (LGS), several alternative treatment options are available. Vagus Nerve Stimulation (VNS) therapy uses a device implanted in the chest that sends mild electrical signals to the brain through the vagus nerve. Studies show that over half of people with LGS experienced at least a 50% reduction in seizures with VNS therapy.
Another surgical option is corpus callosotomy, which involves cutting the nerve bundle connecting the brain's hemispheres to prevent seizures from spreading. Dietary therapies have also shown promise, particularly the ketogenic diet and modified Atkins diet. These high-fat, low-carbohydrate diets have helped many children with LGS achieve better seizure control. Research indicates that nearly half of children following these diets experienced at least a 50% reduction in seizures, with some becoming completely seizure-free. An added benefit is that many people can reduce their medication doses while on these diets.
Cannabidiol (Epidiolex), derived from hemp, is another recently approved treatment option for LGS when traditional medications aren't providing adequate control.
April 8, 2025
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