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Mysoline is a prescription medication approved by the Federal Drug Administration (FDA) in 1954 to control seizure types including psychomotor, grand mal, and focal epileptic seizures. Mysoline is also known by its drug name, Primidone.

Mysoline should not be used in people with a history of porphyria or hypersensitivity to Phenobarbital. Mysoline should be used with caution in people who are depressed or experiencing suicidal thoughts. Mysoline may not be for use by women who are pregnant or breastfeeding.

Mysoline is an anticonvulsant (drug that prevents seizures) of the pyrimidinedione class. It is believed that Mysoline works in cases of epilepsy by inhibiting nerve signals. Phenobarbital is a metabolite, or related drug, of Mysoline. Mysoline may work for people whose seizures have not responded to Phenobarbital.

How do I take it?
Mysoline is taken orally as a tablet three or four times a day. Your physician will likely start you on a low dose of Mysoline and gradually increase the dosage until it becomes effective.

Avoid driving or operating machinery until you are certain you understand how Mysoline affects you.

Mysoline may reduce the effectiveness of some forms of birth control, including oral contraceptives and implants. You may need to adopt another form of birth control while using Mysoline.

Do not stop taking Mysoline suddenly. If you decide to stop taking Mysoline, consult your physician for a plan to taper off gradually.

Always follow your doctor’s instructions exactly when taking Mysoline.

In one study, 622 adults who had partial seizures or secondarily generalized tonic-clonic seizures were treated with Primidone, Phenobarbital, Carbamazepine, or Phenytoin. At the end of one month, there was no significant difference between the effectiveness of Primidone, Carbamazepine, or Phenytoin.

Side effects
Common side effects of Mysoline include fatigue, dizziness, blurry vision, decreased sexual ability, loss of appetite, nausea, vomiting, and uncontrollable eye movements. Some of these side effects may fade as your body acclimates to Mysoline.

Call your doctor if you experience a rash, blurred vision, or unusual bruising or bleeding while taking Mysoline.

Rarely, some people experience neurological symptoms including depression or suicidal thoughts while taking Mysoline. Contact your doctor if you experience these side effects.

Many drugs can cause allergic reactions that, in the most serious cases, can result in death. Seek immediate medical help if you experience signs of a severe allergic reaction such as difficulty breathing or swelling in the face, throat, eyes, lips or tongue.

Mysoline (Primidone) for Epilepsy Questions

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