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I take levetiracetam, zonisamide for my seizures. I take paroxetine for anxiety and depression. I also have migraines. I can't do hormone replacement because it can make my seizures and migraines worse. I have had migraines since my teens and seizures since brain surgery for an AVM in 1994.

June 23
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A MyEpilepsyTeam Member

@A MyEpilepsyTeam Member , Have you tried seeing a Gynecologist? I’m almost 48 & & in August 2024, I officially began menopause , no more premenopause. The hot flashes were just awful & I was hardly getting any sleep at night because I was so hot & I was having to take a little hand held fan with me to bed & had it blowing on me, as well as the regular fan on the dresser in my room & I eventually started taking an ice pack with me to bed as well. My Family doctor had me Progesterone & the Estradiol pill but it wasn’t helping & so she suggested that I go to a Gynecologist. The Gynecologist has kept me on the Progesterone but changed me to the Estradiol Patch & the patch is changed once a week. Now it’s like I’m not even going through menopause & though everyone reacts differently to each medication, I certainly remember the Estradiol Patch. But I did read you have concerns with the hormonal therapy because of your seizures. I did go back & read the side effects of the Estradiol Patch & it recommends to talk to your doctor about it if you have seizures. It also recommends to do so if you have a bleeding disorder & a little over 10 years ago, I was diagnosed with a bleeding disorder called Von Williebrands disorder after my second gum surgery cause the whole right side of my face bruised. I had several different surgeries before that without any problems & so I don’t understand why I suddenly had trouble with that & got diagnosed. But I don’t think it’s extremely bad, but I now have to use a nose spray before any surgery that I have. But I found some information that includes a list of non-hormone therapy for this. But be careful with the Gabapentin because it can possibly effect the memory, cause my Mom took it & she repeated things sometimes & we told her & so she got off it. I don’t know anything about the other medications. But you might talk with a Gynecologist & mention the concern about your seizures & see what they could recommend to help you. Here’s the link to the website with the information: https://share.google/aimode/QTxlwXISK0lHBVe8j . Good luck. Your friend in Austin, Texas, Becky

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June 23
A MyEpilepsyTeam Member

I don't drink alcohol at all and I am very careful about caffeine intake. I have spoken to my neurologist and even he is unsure what to suggest; which is why I asked here.

June 23
MyEpilepsyTeam

Navigating early menopause symptoms alongside epilepsy, migraines, and existing medications is genuinely complex — and it's smart to be cautious about what you add to the mix.

Since hormone replacement therapy isn't an option for you, there are some non-hormonal approaches worth discussing with your neurologist and/or Show Full Answer

Navigating early menopause symptoms alongside epilepsy, migraines, and existing medications is genuinely complex — and it's smart to be cautious about what you add to the mix.

Since hormone replacement therapy isn't an option for you, there are some non-hormonal approaches worth discussing with your neurologist and/or gynecologist:

- Lifestyle changes — Regular exercise, stress reduction techniques like yoga or meditation, and prioritizing sleep can help manage menopause symptoms and may also support seizure control
- Dietary adjustments — Some people find reducing caffeine, spicy foods, and alcohol helps with hot flashes
- Paroxetine (Brisdelle) — Interestingly, you're already taking paroxetine, which is actually FDA-approved in a specific low dose for hot flashes. It's worth asking your doctor if your current dose could be optimized for this purpose One important caution — some over-the-counter remedies like herbal supplements (e.g., black cohosh or St. John's Wort) can interfere with seizure medications or lower the seizure threshold, so it's best to avoid those without checking with your neurologist first.

Given your specific combination of levetiracetam, zonisamide, and paroxetine, your neurologist is really the best person to guide any additions to your regimen to avoid interactions.

June 23

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