MyEpilepsyTeam

Several types of medications can lower the seizure threshold, making seizures more likely. Here's a breakdown:

Prescription Medications
- Bupropion (Wellbutrin) — an antidepressant
- Tramadol — a prescription pain medication
- Certain antibiotics and antipsychotics

Over-the-Counter (OTC) Medications
- Diphenhydramine Show Full Answer

Several types of medications can lower the seizure threshold, making seizures more likely. Here's a breakdown:

Prescription Medications
- Bupropion (Wellbutrin) — an antidepressant
- Tramadol — a prescription pain medication
- Certain antibiotics and antipsychotics

Over-the-Counter (OTC) Medications
- Diphenhydramine (Benadryl) — found in allergy, sleep, and cold products
- Pseudoephedrine and dextromethorphan — common cold medicine ingredients
- Some heartburn medications can also interfere with how anti-seizure drugs work in the body Substances to Avoid
- Alcohol — especially heavy use, can increase seizure risk
- Recreational/illicit drugs — amphetamines, cocaine, MDMA, and synthetic cannabinoids ("spice") are all linked to seizures

It's always a good idea to check with a doctor or pharmacist before taking any new medication — even OTC products — to make sure it won't interact with current anti-seizure medications.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

What Causes First-Time Seizures in Adults?

Which Drugs and Medications Can Raise the Risk of Seizures?