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My newest deep dive.
"There is emerging evidence that endogenous neurosteroids may play a key role in the pathophysiology of catamenial epilepsy, stress–sensitive seizure conditions, temporal lobe epilepsy, and alcohol-withdrawal seizures. It is suggested that neurosteroid replacement with natural or synthetic neurosteroids may be useful in the treatment of epilepsy."
Pregnenolone is the neurosteroid I am focusing on.
The quotes above go back to 2011.
Thoughts? Experience?
@A MyEpilepsyTeam Member - "There is an enormous knowledge gap at the clinical level. We hypothesize the potential role of exogenous NS administration to improve cyclical seizure exacerbation in patients with catamenial epilepsy; for the pregnant women to reduce seizure and medication burden to the mother and foetus; and for peri- and post-menopausal women to reduce seizure burden and improve cognition."
https://www.frontiersin.org/journals/global-wom...
Allow my cynical self to mention that clinical trials, FDA approvals, etc all cost a lot of money. Pharmaceutical companies typically fund the majority of clinical trials, as they have the greatest financial stake in the outcomes of these studies.
The almighty dollar is (unfortunately) always at the forefront.
We are seeing this right now with all of the off label treatments for cancer.
Big Pharma loses when inexpensive and successful alternative cancer treatments are available.
Have there been any trials for it, on animal or human?
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