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Real members of MyEpilepsyTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyEpilepsyTeam Member asked a question 💭
Lancashire

I take lamotrigine which has been great for me, 27 years of taking it, hit that certain age and bam, no warning full tonic clonic, never had one of those always atonic and myoclonic perks, consultant just said breakthrough seizures can happen at any time. Problem I have is that there are some colleagues who have experienced seizures without a diagnosis of epilepsy who are also menopausal and I can't find any research that has investigated this. Any information gratefully received x

June 12, 2025
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A MyEpilepsyTeam Member

I have had more breakthrough seizures since becoming menopausal. My seizures also went from being midday, 2-3 days around my period starting, to being in the late evening. I think it has something to do with hormones, especially because of the time of day. I take phenobarbital and lamotrigine. I have always had tonic-clonic seizures. Two different neurologists have told me that menopause and changes in hormones could affect seizures.

June 20, 2025 (edited)
MyEpilepsyTeam

The connection between hormones and seizures is well-documented. Hormonal changes during menopause can affect seizure patterns since estrogen and progesterone levels fluctuate significantly. Estrogen can increase brain excitability and potentially trigger seizures, while progesterone typically has anti-seizure effects.

The Show Full Answer

The connection between hormones and seizures is well-documented. Hormonal changes during menopause can affect seizure patterns since estrogen and progesterone levels fluctuate significantly. Estrogen can increase brain excitability and potentially trigger seizures, while progesterone typically has anti-seizure effects.

The shift in hormone levels during menopause could explain both your breakthrough seizure and why some people without previous epilepsy diagnoses might experience seizures during this time. It's important to discuss these changes with your neurologist, as your medication needs might need adjustment during this hormonal transition. While breakthrough seizures can happen at any time, the hormonal connection suggests this might not be random and could require specific management strategies.

Consider keeping a detailed diary of any seizure activity and menopause symptoms to help your healthcare team better understand and address the pattern.

June 12, 2025
A MyEpilepsyTeam Member

I haven't had a seizure as a result of menopause. I asked a similar question about this before because I already get hot flashes before me having a seizure. I have both types of seizures which are petit mal and grand mal. I am in the perimenopause stage right now and have had it for 5 years. I wonder the same thing about how a doctor would tell whether if I had a petit mal or grand mal seizure (tonic clonic) as to if it's a result of my Epilepsy or Menopause itself.

June 16, 2025
A MyEpilepsyTeam Member

I get that I just didn't like being dismissed by my neuro and was wondering if anyone else has had a similar experience

June 12, 2025

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A MyEpilepsyTeam Member asked a question 💭