Yes I take 4000mg Keppra a day yes B6 helps

Vitamin B6 is suppose to help some of the emotnal problems associated with Keppra. It works for some and not for others. This would be a subject to take up with your doctor on your next visit if it’s not something he has not suggested before

I've been on Kepra for 17 -18 years now. I also take a multivitamin with my morning meds. I have had anger issues lately, I feel that it is because of forced retirement than anything else. I know I need to work on it. Take care all ericthom3

i take keppra and and pheobarbital. i can not take b6. pheobarb is a Barbiturates. Anticonvulsants (seizure meds) is the other one. b6 helps brain development and for keeping the nervous system and immune system healthy. problem is too much b6 will cause you to muscle control or coordination, Painful and/or disfiguring skin, Heartburn and nausea, photosensitivity, Numbness, and Reduced ability to sense pain or extreme temperatures. do not use if... Altretamine, Barbiturates, Anticonvulsants, Levodopa.
phenobarb is a Barbiturates... and most if not all Anticonvulsants (seizure meds) will not work well.
here's the link of b6 research...
https://www.mayoclinic.org/drugs-supplements-vi...

Vitamin B-6

https://www.mayoclinic.org/drugs-supplements-vitamin-b6/art-20363468

They have me taking 7500 on kepra twice daily and toprimate 125 twice daily and taking vitamin B6 a day helps a lot.